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EDIT: For Windows 10, look for the "Apps and features" section. It says right there "Download the free and easy-to-use IDrive." That's your answer. :) Use of ventricular assist devices (VAD) for prolonged circulatory support has gained widespread acceptance as a therapeutic modality for patients with advanced heart failure. VAD provide effective therapy for patients with refractory heart failure despite significant myocardial remodeling, with improvement in both morbidity and survival. The clinical acceptance of VAD has in large part been supported by clinical studies in which its efficacy has been clearly demonstrated. However, the long-term durability of VAD in these patients is often quite poor. A fundamental limitation of VAD therapy is the tendency for anastomotic sheaths to calcify resulting in subsequent mechanical and hemodynamic failure of the device. This calcification is thought to be caused by calcium phosphate precipitation. The proposed study will investigate the use of an existing clinically used VAD, the DuraHeart (Medtronic), as a model for investigating the mechanism of sheath calcification and then apply this information to the design of a novel anti-calcification coating. The study will first utilize a guinea pig model to demonstrate that a coating consisting of a polymer and active pharmaceutical ingredient can inhibit calcium phosphate precipitation. The coating will then be applied to the DuraHeart and the effect of this coating on calcification of the anastomotic sheath will be assessed. The overall goal of the proposed study is to develop a clinically applicable anti-calcification coating that could be used on the DuraHeart and a variety of VAD. The ultimate goal is to reduce the failure rate of VAD due to calcification of the sheaths. 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